Determination and Risk Assessment of 33 Prohibit Pesticides Residues in Ginkgo Biloba Leaves and the Extracts
10.13748/j.cnki.issn1007-7693.20231297
- VernacularTitle:银杏叶及其提取物中33种禁用农药残留检测分析及风险评估
- Author:
Dandan LIU
1
;
Xiaohong YIN
2
;
Ting HUANG
1
;
Nan DING
2
;
Yutian WANG
1
;
Fangfang WANG
1
;
Ping WU
1
;
Jianbiao YAO
2
Author Information
1. Zhejiang CONBA Pharmaceutical Co., Ltd., Hangzhou 310052, China
2. Zhejiang CONBA Pharmaceutical Co., Ltd., Hangzhou 310052, China；Zhejiang Provincial Key Laboratory of Traditional Chinese Medicine Pharmaceutical Technology, Hangzhou 310052, China
- Publication Type:Journal Article
- Keywords:
Ginkgo Biloba ； Ginkgo Biloba extract ； prohibit pesticide residues ； risk assessment ； risk ranking
- From:
Chinese Journal of Modern Applied Pharmacy
2024;41(4):476-488
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE :To establish the analysis methods of 33 banned pesticides in Ginkgo Biloba leaves and the extracts, and conduct the risk assessment study.
METHODS
One hundred and thirty-six batches of Ginkgo Biloba leaves and 58 batches of Ginkgo Biloba leaves extract were detected by UPLC-MS and GC-MS. The acute and chronic intake risk of pesticide residues in samples were calculated by point assessment method, and the risk scores of the pesticides were calculated by the Britain veterinary residues matrix ranking.
RESULTS
Six kinds of banned pesticides were detected in 136 batches of Ginkgo Biloba leaves, the total detection rate was 35.29%, and the detection amount was 0.002−0.210 mg·kg−1. The chronic dietary intake risk was 0.018%−0.620%, and the acute dietary intake risk was 0.000 1%−0.014 0%, indicated that the dietary exposure risk of pesticides in Ginkgo biloba leaves was at a low level. Two kinds of banned pesticides were detected in 58 batches of Ginkgo Biloba leaves extract, the detection rate was 55.17%, and the detection amount was 0.002−1.788 mg·kg−1. The percentage of acceptable daily intake was 0.003%−0.143%, and the percentage of acute reference dose was 0.002 4%, which was also at a low level. Risk ranking results indicated that the risk of phorate was the highest and should be focused on the production and safety supervision.
CONCLUSION
The method has good stability, high precision and promising repeatability, which can be used for the detection of 33 prohibited pesticides in Ginkgo biloba leaves and their extracts. The results show that the residual amounts of 33 banned pesticides in Ginkgo Biloba leaves and its extracts were extremely low, and there is no significant health risks.
