Intra-tumoral Metastatic Double Primary Carcinoma: Synchronous Metastatic Tumor in Lung from Breast and Thyroid Carcinoma.
- Author:
Lee Chun PARK
1
;
Ji Yun JEONG
;
Jun Ho JI
;
Silvia PARK
;
Jin Seok AHN
;
Young Hyuck IM
;
Yeon Hee PARK
Author Information
1. Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. yhparkhmo@skku.edu
- Publication Type:Case Report
- Keywords:
Double primary tumor;
Neoplasm metastasis;
Intra-tumoral heterogeneity
- MeSH:
Adult;
Breast Neoplasms;
Breast*;
Carcinoma, Ductal;
Carcinoma, Papillary;
Estrogens;
Female;
Humans;
Iodine;
Lung*;
Metastasectomy;
Neoplasm Metastasis;
Population Characteristics;
Thoracic Surgery, Video-Assisted;
Thyroid Gland;
Thyroid Neoplasms*
- From:Cancer Research and Treatment
2014;46(2):200-203
- CountryRepublic of Korea
- Language:English
-
Abstract:
Cases of phenotypic heterogeneity of cells within tumors have recently been reported. Here, we report on a patient with characteristic intra-tumor double primary metastases in the lung. This patient was a 40-year-old Korean woman who had been diagnosed with breast cancer (T1N0M0, estrogen receptor/progesterone receptor/HER2 +/+/+) and papillary thyroid cancer three years prior and underwent a complete surgical resection followed by appropriate adjuvant treatment with radiation, hormone, and radioactive iodine. She was recently admitted for newly developed pulmonary nodules. Metastasectomy through video-assisted thoracoscopic surgery revealed recurrent double primary cancer with two different components (metastatic ductal carcinomas from the breast and metastatic papillary carcinomas from the thyroid gland) in each pulmonary nodule in the right upper lobe and right middle lobe. To the best of our knowledge, this is the first report of simultaneous recurrent double metastasis in one organ from different primary origins.
