Tumor Lysis Syndrome in a Patient with Metastatic Colon Cancer after Treatment with 5-Fluorouracil/Leucovorin and Oxaliplatin: Case Report and Literature Review.
- Author:
Hyung Duk KIM
1
;
Kyung Sun HA
;
In Sook WOO
;
Yun Hwa JUNG
;
Chi Wha HAN
;
Tae Jung KIM
Author Information
1. Department of Internal Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea. insookwoo@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Tumor lysis syndrome;
Oxaliplatin;
Colon
- MeSH:
Colon;
Colonic Neoplasms*;
Colorectal Neoplasms;
Drug Therapy;
Fluorouracil;
Hematologic Neoplasms;
Humans;
Leucovorin;
Middle Aged;
Tumor Lysis Syndrome*
- From:Cancer Research and Treatment
2014;46(2):204-207
- CountryRepublic of Korea
- Language:English
-
Abstract:
Development of tumor lysis syndrome (TLS) may occur after chemotherapy or spontaneously in bulky or rapidly growing tumors. This syndrome is frequent but preventable in patients with hematologic malignancies. TLS following therapy has been reported infrequently in various types of solid tumors. TLS associated with oxaliplatin containing chemotherapy in a solid tumor has never been reported. A 59-year-old man received 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) chemotherapy for metastatic colon cancer. Development of TLS occurred three days after administration of chemotherapy. Two days later, his abnormal laboratory findings were recovered with appropriate management. To the best of our knowledge, the current case is the first report on development of acute TLS following oxaliplatin containing chemotherapy in a patient with colon cancer. We also review the literature on tumor lysis syndrome in patients with colorectal cancer.
