Glioblastoma in a Patient with Neurofibromatosis Type 1: A Case Report and Review of the Literature.
10.14791/btrt.2014.2.1.36
- Author:
Tae Seok JEONG
1
;
Gi Taek YEE
Author Information
1. Department of Neurosurgery, Gil Medical Center, Gachon University, Incheon, Korea. gtyee@gilhospital.com
- Publication Type:Case Report
- Keywords:
Glioblastoma;
Neurofibromatosis type 1;
CCRT;
Temozolomide
- MeSH:
Adult;
Astrocytoma;
Brain Neoplasms;
Drug Therapy;
Glioblastoma*;
Hand;
Headache;
Humans;
Male;
Neurofibromatosis 1*;
Optic Nerve Glioma;
Pathology
- From:Brain Tumor Research and Treatment
2014;2(1):36-38
- CountryRepublic of Korea
- Language:English
-
Abstract:
Neurofibromatosis type 1 (NF1) is an autosomal dominantly inherited familial tumor syndrome. Benign tumors such as pilocytic astrocytoma, optic glioma make up the majority of intracranial neoplasms in patients with NF1. There have only been a handful of cases in which adult glioblastoma presented with NF1. A 32-year-old male presented with headache and radiological studies showing a high grade intra-axial tumor. The patient underwent gross total surgical excision and the pathology revealed glioblastoma. After the surgery, he received concomitant chemo-radiotherapy with temozolomide and adjuvant temozolomide chemotherapy. We report a NF1 patient who developed glioblastoma and reviewed related articles.
