Chronic-Binge Ethanol Drinking Exacerbates Liver Damage through Oxidative/Nitrosative Stress.
- Author:
In Hoon NA
1
;
Seong Ho YOO
Author Information
1. Department of Rehabilitation Medicine, Catholic Medical Center, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
alcohol;
oxidative stress;
steatosis
- MeSH:
Alcohol Drinking;
Animals;
Catalase;
Drinking;
Ethanol;
Glutathione Peroxidase;
Hepatitis, Chronic;
Liver;
Liver Cirrhosis;
Liver Diseases;
Mice;
Oxidative Stress;
Superoxide Dismutase
- From:Korean Journal of Legal Medicine
2011;35(1):22-26
- CountryRepublic of Korea
- Language:English
-
Abstract:
Chronic binge alcohol drinking is a major cause of liver disease including steatosis, chronic hepatitis, and liver cirrhosis. The purpose of this study is to examine the change of oxidative/nitrosative stress in the chronic-binge ethanol model. Using wildtype (WT) mice, we show that chronic binge alcohol drinking develops steatosis and apoptotic cells. Furthermore, the activities of anti-oxidant and mitochondrial enzymes including catalase (CAT), superoxide dismutase 1 (SOD1) and glutathione peroxidase (GPx) were decreased in chronic binge alcohol-treated mice. Protein nitration was also increased in a chronic-binge group compared to pair-fed control counterpart. These findings suggest that chronic binge alcohol drinking plays a critical role in hepatic injury through oxidative/nitrosative stress.
