Ideal Experimental Rat Models for Liver Diseases.
10.14701/kjhbps.2011.15.2.67
- Author:
Sang Woo LEE
1
;
Sung Hoon KIM
;
Seon Ok MIN
;
Kyung Sik KIM
Author Information
1. Department of Surgery, Yonsei University College of Medicine, Korea. kskim88@yuhs.ac
- Publication Type:Review
- Keywords:
Liver disease;
Animal model;
Rat
- MeSH:
Animals;
Animals, Laboratory;
Humans;
Liver;
Liver Diseases;
Models, Animal;
Rats;
Social Control, Formal
- From:Korean Journal of Hepato-Biliary-Pancreatic Surgery
2011;15(2):67-77
- CountryRepublic of Korea
- Language:English
-
Abstract:
There are many limitations for conducting liver disease research in human beings due to the high cost and potential ethical issues. For this reason, conducting a study that is difficult to perform in humans using appropriate animal models, can be beneficial in ascertaining the pathological physiology, and in developing new treatment modalities. However, it is difficult to determine the appropriate animal model which is suitable for research purposes, since every patient has different and diverse clinical symptoms, adverse reactions, and complications due to the pathological physiology. Also, it is not easy to reproduce identically various clinical situations in animal models. Recently, the Guide for the Care and Use of Laboratory Animals has tightened up the regulations, and therefore it is advisable to select the appropriate animals and decide upon the appropriate quantities through scientific and systemic considerations before conducting animal testing. Therefore, in this review article the authors examined various white rat animal testing models and determined the appropriate usable rat model, and the pros and cons of its application in liver disease research. The authors believe that this review will be beneficial in selecting proper laboratory animals for research purposes.
