Risk Factors for Intrahepatic Recurrence.
10.14701/kjhbps.2011.15.2.83
- Author:
Myung Hee YOON
1
;
Young Il CHOI
;
Kwang Kuk PARK
;
Dong Hoon SHIN
;
Chung Han LEE
Author Information
1. Department of Surgery, Gospel Hospital, College of Medicine, Kosin University, Korea. ymh479@kosinmed.or.kr
- Publication Type:Original Article
- Keywords:
Hepatocellular carcinoma;
Intrahepatic recurrence;
HBV infection;
Risk factor
- MeSH:
Aspartate Aminotransferases;
Carcinoma, Hepatocellular;
Follow-Up Studies;
Hepatitis B virus;
Hepatitis B, Chronic;
Humans;
Liver;
Organization and Administration;
Recurrence;
Risk Factors;
Survival Rate;
Viruses
- From:Korean Journal of Hepato-Biliary-Pancreatic Surgery
2011;15(2):83-89
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Although surgical resection offers patients with HCC the chance of a cure, the post-resection tumor recurrence rate is high, with reported cumulative 5-year tumor recurrence rates ranging from 40 to 70%. The objective of this study was to investigate risk factors for intrahepatic recurrence after resection of hepatocellular carcinoma, especially in patients with hepatitis B virus infection. METHODS: Between January 1999 and December 2003, 59 patients in our Hospital with hepatitis B virus infection underwent liver resection for hepatocellular carcinoma. Clinical, biological, and histopathological characteristics of these patients were collected and tested for their prognostic significance using a Chi-square test and a Student's t-test. Time to recurrence and survival rate were analyzed by the Kaplan-Meier method. RESULTS: Of the 59 patients who underwent liver resection, 24 (41%) experienced intrahepatic recurrence. The 1-, 3-, and 5-year overall survival rates of total enrolled patients were 83%, 63%, and 42%, respectively. The 1-, 3-, and 5-year overall survival rates after recurrence were 87%, 52%, and 20%, respectively. The risk factors for early recurrence were elevated serum aspartate aminotransferase (AST) level (p=0.044) and larger tumor size (p=0.049). For late recurrence, greater tumor size (p=0.039) was the only risk factor. CONCLUSION: Tumor size and serum aspartate aminotransferase are risk factors of intrahepatic recurrence after resection of HCC in patients with chronic hepatitis B virus infection. This finding indicates that patients who have these risk factors should be under more careful supervision and have more aggressive follow-up.
