Clinical characteristics of chronic sclerosing sialadenitis as a distinctive entity from primary Sjögren’s syndrome
- Author:
Eui-Jong KWON
1
;
Youngjae PARK
;
Seung-Ki KWOK
;
Ji Hyeon JU
Author Information
- Publication Type:Original Article
- From:Journal of Rheumatic Diseases 2024;31(4):230-243
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objective:This study aimed to elucidate the clinical and laboratory differences between chronic sclerosing sialadenitis (CSS) and primary Sjögren’s syndrome (pSS), highlighting CSS as a distinct pathological entity within the spectrum of salivary gland pathology.
Methods:This retrospective, single-center study was conducted at Seoul St. Mary’s Hospital between January 2000 and December 2022. Patients diagnosed with CSS via salivary gland biopsy were included, and those with IgG4-related disease (IgG4-RD) or other confounding factors were excluded. Clinical and laboratory CSS profiles were compared with those of a control group of patients with typical pSS from the Korean Initiative of Primary Sjögren’s Syndrome (KISS) prospective cohort study. Twenty-one with CSS and 501 patients with pSS from Seoul St. Mary’s Hospital were retrospectively analyzed.
Results:Patients with CSS were older at diagnosis, had a lower prevalence of ocular symptoms, and exhibited distinct immunological markers compared to those with pSS. Logistic regression analysis revealed that anti-Ro antibody positivity, elevated erythrocyte sedimentation rate levels, low serum complement 3 levels, and accompanying dry eye symptoms were factors distinguishing pSS from CSS.
Conclusion:Even after excluding IgG4-RD, CSS was significantly different from pSS in terms of clinical and laboratory findings.Recognition of these differences is crucial for the accurate diagnosis and management of CSS, underscoring its status as a distinct pathological entity among salivary gland pathologies.
