Metabolic syndrome criteria as predictors of subclinical atherosclerosis based on the coronary calcium score.
10.3904/kjim.2015.30.1.73
- Author:
Mi Hae SEO
1
;
Eun Jung RHEE
;
Se Eun PARK
;
Cheol Young PARK
;
Ki Won OH
;
Sung Woo PARK
;
Won Young LEE
Author Information
1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, Gumi, Korea.
- Publication Type:Original Article
- Keywords:
Coronary artery;
Calcification;
Metabolic syndrome
- MeSH:
Adult;
Asymptomatic Diseases;
Biological Markers/blood;
Calcium/*analysis;
Coronary Angiography/methods;
Coronary Artery Disease/blood/*epidemiology/radiography;
Coronary Vessels/*chemistry/radiography;
Cross-Sectional Studies;
Female;
Humans;
Male;
Metabolic Syndrome X/blood/diagnosis/*epidemiology;
Middle Aged;
Multidetector Computed Tomography;
Multivariate Analysis;
Odds Ratio;
Predictive Value of Tests;
Prevalence;
Republic of Korea/epidemiology;
Risk Assessment;
Risk Factors;
Vascular Calcification/blood/*epidemiology/metabolism/radiography
- From:The Korean Journal of Internal Medicine
2015;30(1):73-81
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: The aim was to determine which of three sets of metabolic syndrome (MetS) criteria (International Diabetes Federation [IDF], National Cholesterol Education Program Adult Treatment Panel III [ATP III], and European Group for the Study of Insulin Resistance [EGIR]) best predicts the coronary artery calcification (CAC) score in a cross-sectional study. This has not been evaluated in previous studies. METHODS: A total of 24,060 subjects were screened for CAC by multi-detector computed tomography. The presence of CAC was defined as a CAC score > 0. The odds ratio for the presence of CAC was analyzed for three different sets of MetS criteria and according to number of MetS components. RESULTS: CAC was observed in 12.6% (3,037) of the subjects. Patients with MetS, as defined by the IDF, ATP III, and EGIR criteria, had a CAC rate of 23.0%, 25.1%, and 29.5%, respectively (p < 0.001). Comparisons of C statistics for multivariate regression models revealed no significant difference among the three sets of criteria. After adjustment for risk factors, the ATP III criteria produced a slightly higher odds ratio for CAC compared with the other criteria, but this difference was not significant. The risk factor-adjusted odds ratio for the presence of CAC increased from 1 to 1.679 as the number of MetS components defined by ATP III increased from 0 to > or = 3 (p for trend < 0.001). CONCLUSIONS: The presence of MetS was associated with the presence of CAC. There was no significant difference among the three sets of MetS criteria in terms of the ability to predict CAC. An increase in the number of MetS components was associated with an increased odds of CAC.
