The association between an abnormal post-voiding urine volume and a lower estimated glomerular filtration rate in patients with type 2 diabetes with no voiding symptoms.
10.3904/kjim.2015.30.1.82
- Author:
Jin A CHO
1
;
Sung Tae CHO
;
Young Ki LEE
;
Jieun OH
;
Sung Gyun KIM
;
Jang Won SEO
;
Jong Woo YOON
;
Ja Ryong KOO
;
Hyung Jik KIM
;
Yong Seong LEE
;
Young Goo LEE
;
Jung Woo NOH
Author Information
1. Department of Internal Medicine and Hallym Kidney Research Institute, Seoul, Korea. jwn8671@unitel.co.kr
- Publication Type:Original Article
- Keywords:
Diabetic nephropathies;
Diabetes complications;
Diabetes mellitus;
Residual volume
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Diabetes Mellitus, Type 2/*complications/diagnosis;
Diabetic Nephropathies/diagnosis/*etiology/physiopathology;
Female;
*Glomerular Filtration Rate;
Humans;
Kidney/*physiopathology;
Logistic Models;
Male;
Middle Aged;
Multivariate Analysis;
Odds Ratio;
Outpatient Clinics, Hospital;
Republic of Korea;
Risk Factors;
Time Factors;
*Urodynamics
- From:The Korean Journal of Internal Medicine
2015;30(1):82-87
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Diabetic cystopathy is a frequent complication of diabetes mellitus. This study assessed the association between the post-voiding residual (PVR) urine volume and diabetic nephropathy in type 2 diabetics with no voiding symptoms. METHODS: This study investigated 42 patients with type 2 diabetes who were followed regularly at our outpatient clinic between July 1, 2008 and June 30, 2009. No patient had voiding problems or International Prostate Symptom Scores (IPSSs) > or = 12. An urologist performed the urological evaluations and the PVR was measured using a bladder scan. A PVR > 50 mL on two consecutive voids was considered abnormal, which was the primary study outcome. RESULTS: The mean patient age was 60 +/- 10 years; the IPSS score was 3.7 +/- 3.3; and the diabetes duration was 11.9 +/- 7.8 years. Seven of the 42 patients (16.7%) had a PVR > 50 mL. The presence of overt proteinuria or microalbuminuria was associated with an increased risk of a PVR > 50 mL (p < 0.01). Patients with a PVR > 50 mL had a significantly lower estimated glomerular filtration rate (eGFR) compared with those with a PVR < or = 50 mL (59.2 +/- 27.1 mL/min/1.73 m2 vs. 28.7 +/- 23.3 mL/min/1.73 m2; p < 0.001). Multivariate logistic analysis revealed that a lower eGFR (odds ratio, 0.94; 95% confidence interval, 0.88 to 0.99; p = 0.04) was a significant risk factor for a PVR > 50 mL. CONCLUSIONS: Patients with diabetic nephropathy had a significantly higher PVR and a lower eGFR was associated with an abnormal PVR.
