Effects of Antipsychotic Drugs on Cellular lmmunity in Mice.
- Author:
Kyung Hee KIM
1
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: Chlorpromazine; haloperidol; peripheral blood white blood cell (WBC) and lymphocyte count; T-lymphocytes of the thymus and spleen; in-vitro lymphocyte response to PHA; in-vitro study for delayed type of hypersensitivity; male ICR mice
- MeSH: Animal; Antipsychotic Agents/toxicity*; Immune Tolerance/drug effects; Immunity, Cellular/drug effects*; Male; Mice; Mice, Inbred ICR
- From:Yonsei Medical Journal 1986;27(1):59-66
- CountryRepublic of Korea
- Language:English
- Abstract: The effects of the two antipsychotic drugs, chlorpromazine and haloperidol, the focus of this study, on cell-mediated immunity in male ICR mice. The peripheral blood WBC count decreased significantly in both cholorpromazine and haloperidol. The absolute lymphocyte count decreased only in the haloperidol-treated groups. The absolute number of thy-1-bearing cells described in both the chlorpromazine and haloperidol groups, the most remarkable effects evidencing itrself in the booster groups of higher dosage chlorpromazine (15 mg/kg), and lower and higher-dosage haloperidol (1 mg/kg and 5 mg/kg). The absolute spleen T-lymphocyte count was decreased significantly in the chlorpromazine higher-dosage booster-dose group and the haloperidol higher-dosage (5 mg/kg) single-dose group and the haloperidol lower and higher-dosage (1 mg/kg and 5mg/kg) booster-dose group. Also, chlorpromazine and haloperidol significantly impaired the in-vitro lymphocyte response to phytohemagglutinin (PHA) and produced a negative reaction of the delayed-hypersensitivity type induced by BCG vaccination. These findings suggest that chlorpromazine and haloperidol suppress the cellular immune responses in mouse.
