Urokinase, urokinase receptor, and plasminogen activator inhibitor-1 expression on podocytes in immunoglobulin A glomerulonephritis.
10.3904/kjim.2014.29.2.176
- Author:
Ji Hye LEE
1
;
Mee Hye OH
;
Jae Seok PARK
;
Gyoung Jae NA
;
Hye Wook GIL
;
Jong Oh YANG
;
Eun Young LEE
;
Sae Yong HONG
Author Information
1. Department of Pathology, Soonchunhyang University College of Medicine, Cheonan, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Glomerulonephritis, IGA;
Plasminogen activator inhibitor 1;
Urokinase-type plasminogen activator;
Receptors, urokinase plasminogen activator
- MeSH:
Adolescent;
Adult;
Aged;
Atrophy;
Biological Markers/analysis;
Biopsy;
Female;
Fibrosis;
Glomerulonephritis, IGA/diagnosis/*enzymology/immunology;
Humans;
Immunohistochemistry;
Male;
Middle Aged;
Plasminogen Activator Inhibitor 1/*analysis;
Podocytes/*enzymology/immunology/pathology;
Receptors, Urokinase Plasminogen Activator/*analysis;
Urokinase-Type Plasminogen Activator/*analysis;
Young Adult
- From:The Korean Journal of Internal Medicine
2014;29(2):176-182
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: The purpose of this study was to investigate the expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 on podocytes in immunoglobulin A (IgA) glomerulonephritis (GN). METHODS: Renal biopsy specimens from 52 IgA GN patients were deparaffinized and subjected to immunohistochemical staining for uPA, PAI-1, and uPAR. The biopsies were classified into three groups according to the expression of uPA and uPAR on podocytes: uPA, uPAR, and a negative group. The prevalences of the variables of the Oxford classification for IgA GN were compared among the groups. RESULTS: On podocytes, uPA was positive in 11 cases and uPAR was positive in 38 cases; by contrast, PAI-1 was negative in all cases. Expression of both uPA and uPAR on podocytes was less frequently accompanied by tubulointerstitial fibrosis. CONCLUSIONS: Our results suggest a possible protective effect of podocyte uPA/uPAR expression against interstitial fibrosis.
