The relationship between Helicobacter pylori eradication and gastric cancer in middle-aged and elderly population
10.3969/j.issn.1006-2483.2024.06.023
- VernacularTitle:幽门螺杆菌根除与中老年人群胃癌发生关联分析
- Author:
Jie ZHOU
1
;
Fanqian YANG
1
;
Yukai ZHU
1
;
Yukai ZHU
1
;
Mengyin PENG
1
;
Miao WU
1
Author Information
1. Gastroenterology Department , Affiliated Hospital of Southwest Medical University , Luzhou , Sichuan 646000 , China
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Eradication;
Gastric cancer;
Association
- From:
Journal of Public Health and Preventive Medicine
2024;35(6):101-104
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the incidence and mortality of gastric cancer in middle-aged and elderly population after Helicobacter pylori eradication , and provide theoretical guidance for the prevention of this disease in Luzhou area. Methods A total of 541 patients with Helicobacter pylori eradication from 2019 to 2021 were selected , they were divided into control group and observation group according to whether they developed gastric cancer in later stage, patients with gastric cancer due to Helicobacter pylori infection were selected as positive control group (N=205) . In addition, the expression of tumor markers such as CEA, CA199, CA125 and proliferation-related factor Ki67 were compared among the three groups, binary Logistic regression was used to analyze the risk factors of gastric cancer in the middle-aged and elderly population after Helicobacter pylori eradication. Results Among the 39(7.21%) of 541 patients developed gastric cancer after HP eradication , including 23males and 16females, with no gender difference (P>0.05) .The positive rate of moderate and severe atrophy of gastric mucosa and the ratio of PPI ≥1 year in the observation group were higher than those in the control group (P<0.05) . In addition , serum CEA , CA199 , CA125 levels were the highest in the positive control group , followed by the observation group , Ki67 expression was also the same. Logistic regression analysis showed that PPI ≥1 year (OR=1.642) , gastric mucosal atrophy (OR=1.459) or severe (OR=3.271) and presence of IM (OR= 3.669) were independent risk factors for gastric cancer after Hp eradication. Conclusion The risk of developing gastric cancer was higher in the middle-aged and elderly after Helicobacter pylori eradication , and the risk of developing gastric cancer was higher in patients with moderate or severe atrophy of gastric mucosa , PPI ≥1 year and having IM , gastroscopic screening should be strengthened to prevent gastric cancer..
