Bacterial pathogen spectrum and drug resistance in respiratory intensive care unit in 2020- 2022
10.3969/j.issn.1006-2483.2024.06.020
- VernacularTitle:2020—2022年呼吸重症监护室细菌病原谱及耐药性分析
- Author:
Juan LI
1
,
2
;
Tu LYU
2
;
Lina FENG
1
;
Qianyu FENG
1
;
Yun HUANG
1
;
Congrong LI
1
;
Xuan CAI
1
Author Information
1. Department of Clinical Laboratory , Renmin Hospital of Wuhan University , Wuhan , Hubei 430060 , China
2. Hubei Provincial Centre for Disease Control and Prevention , Wuhan , Hubei 430079 , China
- Publication Type:Journal Article
- Keywords:
Respiratory intensive care unit;
Bacterial infection;
Pathogen spectrum;
Drug resistance;
Rational drug use
- From:
Journal of Public Health and Preventive Medicine
2024;35(6):89-92
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the infectious pathogen characteristics and drug sensitivity of hospitalized patients in the respiratory intensive care unit (RICU) of Renmin Hospital of Wuhan University. Methods Bacterial culture samples sent to the RICU of our hospital from January 2020 to December 2022 were retrospectively analyzed. The bacterial types were identified by Bruker mass spectrometer, and the Phoenix 100 was used for drug sensitivity analysis. The antimicrobial susceptibility was analyzed by WHONET 5.6 software. Results A total of 1 157 strains of bacteria were isolated, including 878 strains of Gram-negative bacteria (75.89%) and 279 strains of Gram-positive bacteria (24.11%). The top five with the highest detection rate were Acinetobacter baumannii (25.50%), Pseudomonas aeruginosa (18.76%), Klebsiella pneumoniae (13.83%), Staphylococcus aureus (6.57%) and Escherichia coli (5.70%). Among them, Acinetobacter baumannii was extremely drug-resistant, only showing relatively high sensitivity to colistin, minocycline, and tigecycline. Staphylococcus aureus accounted for the highest proportion of Gram-positive bacteria (6.57%), with methicillin-resistant Staphylococcus (MRSA) showing a continuous increase. Conclusion In the past three years, Gram-negative bacteria have been the main pathogenic bacteria detected in the respiratory intensive care unit of our hospital. The main bacteria are Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae, which have a high resistance rate to various antibiotics. Therefore, clinical monitoring of resistant strains in RICU should be strengthened to facilitate rational use of antibiotics and improve antibacterial effect.
