Effect of vaccination on the incidence of hemorrhagic fever with renal syndrome in Jingzhou
10.3969/j.issn.1006-2483.2024.06.018
- VernacularTitle:疫苗接种对荆州市肾综合征出血热发病影响分析
- Author:
Tian LIU
1
,
2
;
Menglei YAO
1
;
Qingbo HOU
1
;
Jigui HUANG
1
;
Yang WU
3
;
Man LIU
3
;
Kaifa SONG
1
;
Bing HU
3
Author Information
1. Department for Infectious Disease Control and Prevention, Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei 434000 , China
2. Public Health Research Center, Yangtze University, Jingzhou, Hubei 434000, China
3. Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei 430079, China
- Publication Type:Journal Article
- Keywords:
Hemorrhagic fever with renal syndrome;
Vaccine;
Serological surveillance;
Vaccination
- From:
Journal of Public Health and Preventive Medicine
2024;35(6):81-84
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the current status of emergency vaccination of hemorrhagic fever with renal syndrome (HFRS) vaccine in Jingzhou, serological monitoring and the incidence of vaccinated population, and to evaluate the protective effect of emergency vaccination of HFRS vaccine on the control of HFRS epidemic in the city. Methods From 2018 to 2020, HFRS vaccination was carried out in Jianli City, Honghu City, Jiangling County, Gongan County and some townships in Shashi City, Jingzhou City, focusing on people aged 30-59 years old. The incidence of HFRS, vaccination history of cases and HFRS vaccination data of Jingzhou City were collected and analyzed by descriptive epidemiological methods. The sera of those who had not been vaccinated with HFRS vaccine (non-vaccinated group) and those who had been vaccinated with HFRS vaccine (vaccinated group) were collected for IgG antibody detection, and the serum IgG was detected by ELISA method. The correlation between the change in the number of cases in townships where people were vaccinated (comparison between 2017-2018 and 2020) and the vaccination rate before 2019 was analyzed. Results A total of 446 900 doses of HFRS vaccine were vaccinated from 2018 to 2020, covering 22 townships in 5 counties and cities, accounting for 17.19% (22/128) of the total number of townships in the city. A total of 120 953 people completed 3 doses of vaccination, accounting for 11.30% of the total population and 23.77% of the population aged 30-59 in the vaccinated township. The positive rate of IgG in the unvaccinated group in Jingzhou was 9.91% (85/858). The positive rate of IgG in the vaccination group was 40.96% (34/83). The positive rates of IgG in the 1-dose group, 2- dose group, and 3-dose group were 0 (0/2), 18.18% (6/33), and 58.33% (28/48), respectively. From 2017 to 2020, a total of 16 cases had been vaccinated with HFRS before the onset of the disease, and 81.25% (13/16) received 2 doses or less of HFRS vaccine. The changes in the number of cases was negatively correlated with the vaccination rate of the whole population in townships where people were vaccinated (rs=-0.58, P=0.011). The changes in the number of cases was negatively correlated with the vaccination rate of people aged 30-59 years in townships where people were vaccinated (rs=-0.46, P=0.055). Conclusion The HFRS vaccination before 2019 has played a certain protective effect on the vaccinated population. However, the inoculation rate of HFRS vaccine in Jingzhou City is still low, and the protective effect on the whole population has not yet appeared.
