A Case of Epilepsy Exhibiting a Severe, Dose-Dependent, Memory Deficit after Zonisamide Administration.
- Author:
Jong Mok LEE
1
;
Jong Geun SEO
;
Sun Young KIM
;
Yang Ha HWANG
;
Ho Won LEE
;
Chung Kyu SUH
;
Soon Hak KWON
;
Sung Pa PARK
Author Information
1. Department of Neurology, School of Medicine, Kyungpook National University, Daegu, Korea. sppark@mail.knu.ac.kr
- Publication Type:Case Report
- Keywords:
Epilepsy;
Memory deficit;
Zonisamide
- MeSH:
Aged;
Epilepsy;
Humans;
Isoxazoles;
Memory;
Memory Disorders;
Seizures;
Valproic Acid
- From:Journal of Korean Epilepsy Society
2008;12(1):52-54
- CountryRepublic of Korea
- Language:English
-
Abstract:
Zonisamide (ZNS) has been proven as a safe, effective, and well-tolerated antiepileptic drug. We report an epilepsy patient who had a severe, dose-dependent, memory deficit after ZNS administration. A 65-year-old man visited our epilepsy clinic due to the occurrence of nocturnal convulsions. Despite the absence of seizures, he developed a severe impairment of verbal and visual memory functions after the increment of ZNS dosage from 200 mg/day to 300 mg/day. We substituted 1,000 mg/day valproic acid for ZNS. His cognitive performances were returned to original levels.
