Pharmacokinetics of oxytetracycline in hybrid catfish (Clarias macrocephalus x C. gariepinus) after intravascular and oral administrations
- Author:
Amnart POAPOLATHEP
1
;
Kednapat SRIPHAIROJ
;
Sittichai HATACHOTE
;
Kannika WONGPANIT
;
Duangkamol SAENSAWATH
;
Narumol KLANGKAEW
;
Napasorn PHAOCHOOSAK
;
Mario GIORGI
;
Saranya POAPOLATHEP
Author Information
- Publication Type:Research Report
- From:Journal of Veterinary Science 2024;25(4):e58-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objective:This study was designed to evaluate the pharmacokinetic characteristics of oxytetracycline (OTC) in the hybrid catfish, following single intravascular (IV) or oral (PO) administration at a single dosage of 50 mg/kg body weight (BW).
Methods:In total, 140 catfish (each about 100–120 g BW) were divided into two groups (n = 70). Blood samples (0.6–0.8 mL) were collected from ventral caudal vein at pre-assigned times up to 144 h (sparse samples design). OTC plasma concentrations were analyzed using high-performance liquid chromatography-photodiode array detector.
Results:The pharmacokinetic parameter of OTC was evaluated using a non-compartment model. OTC plasma concentrations were detectable for up to 144 and 120 h after IV and PO, respectively. The elimination half-life value of OTC was long with slow clearance after IV administration in hybrid catfish. The average maximum concentration value of OTC was 2.72 µg/mL with a time at the maximum concentration of 8 h. The absolute PO bioavailability was low (2.47%).
Conclusions:and Relevance: These results showed that PO administration of OTC at a dosage of 50 mg/kg BW was unlikely to be effective for clinical use in catfish. The pharmacodynamic properties and clinical efficacy of OTC after multiple medicated feed are warranted.
