A case of double primary gastric adenocarcinoma and duodenal carcinoma with osteoclast-like giant cells.
- Author:
Sang Jun PARK
1
;
Jun Hee LEE
;
Seung Youn KIM
;
Hyeon Sin PARK
;
Kye Sook KWON
;
Hyeon Geun CHO
;
Don Haeng LEE
;
Pum Soo KIM
;
Hyung Gil KIM
;
Yong Woon SHIN
;
Young Soo KIM
;
Joon Mee KIM
;
Kyung Rae KIM
Author Information
1. Department of Internal Medicine, College of Medicine, Inha University, Songnam, Korea. YWShin@inha.ac.kr
- Publication Type:Case Report
- Keywords:
Osteoclasts;
Giant cells;
Duodenal neoplasms
- MeSH:
Adenocarcinoma*;
Aged;
Breast;
Carcinoembryonic Antigen;
Carcinoma;
Coloring Agents;
Duodenal Neoplasms;
Duodenum;
Gastric Bypass;
Giant Cells*;
Humans;
Immunohistochemistry;
Intestinal Obstruction;
Keratins;
Liver;
Molecular Weight;
Neoplasm Metastasis;
Osteoclasts;
Pancreas;
Stomach;
Thyroid Gland;
Vimentin;
Weight Loss
- From:Korean Journal of Medicine
2001;61(2):156-161
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Osteoclast like giant cells (OGCs) are infrequently encountered in a number of malignancies in extraosseous sites, such as the breast, pancreas, liver, stomach, thyroid gland, and other organs. Immunohistochemical stains demonstrate that the OGCs are of monocytic or histiocytic origin and probably represent a distinctive host response to the tumor. The OGCs show strong reactivity with CD68, and no reactivity with cytokeratin or polyclonal antibody to carcinoembryonic antigen (CEA). We experienced a 70 year old man who presented with epigastric pain and weight loss, and found synchronous duodenal carcinoma with OGCs and gastric adenocarcinoma. Histological examination showed an undifferentiated carcinoma with evenly scattered OGCs in the duodenum and liver metastases. OGCs were never seen to undergo mitotic division or exhibit atypia. By immunohistochemistry, neoplastic cells were diffusely positive for vimentin and focally positive for CAM 5.2 (low molecular weight cytokeratin), but OGCs were positive for only vimentin. He underwent palliative gastrojejunostomy for intestinal obstruction due to a large duodenal neoplasm. We report a case of synchronous double primary cancer of gastric adenocarcinoma and duodenal carcinoma with OGCs in a 70 year old man which was proved histopathologically.
