A case of lymphocytic infundibuloneurohypophysitis presenting as central diabetes insipidus and nodular mass on neurohypophysis.
- Author:
Gun Young CHO
1
;
Jong Ryeal HAHM
;
Ji Hyang KIM
;
Tae Wook KANG
;
In Kyung CHUNG
;
Tae Young YANG
;
Jae Hoon CHUNG
;
Yong Ki MIN
;
Myung Shik LEE
;
Moon Kyu LEE
;
Youn Lim SE
;
Kwang Won KIM
Author Information
1. Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. cgyks@hanmail.net
- Publication Type:Case Report
- Keywords:
Lymphocyte;
Pituitary gland, Posterior;
Diabetes insipidus, Neurogenic;
MRI scan
- MeSH:
Adenoma;
Diabetes Insipidus, Neurogenic*;
Granuloma;
Humans;
Lymphocytes;
Magnetic Resonance Imaging;
Middle Aged;
Pituitary Gland;
Pituitary Gland, Anterior;
Pituitary Gland, Posterior*;
Plasma Cells;
Polydipsia;
Polyuria;
Sarcoidosis;
Thyrotropin;
Thyrotropin-Releasing Hormone;
Water Deprivation
- From:Korean Journal of Medicine
2001;61(2):168-172
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Lymphocytic infundibuloneurohypophysitis was known as a cause of idiopathic central diabetes insipidus. Until recent time, it is characterized into two groups. One has thickening of the pitutitary stalk, enlargement of the neurohypophysis and loss of hyperintense signal of the normal neurohypophysis, the other has only loss of hyperintense signal but not morphological change. A 51-year-old man presented with a one month history of polydipsia and polyuria. The interpretation of water deprivation test was compatible with complete central diabetes insipidus. Endocrinologic examination of the adenohypophysis hormones and its triple stimulation test were normal apart from thyroid stimulating hormone (TSH), which showed low response despite thyrotropin releasing hormone (TRH). Sellar MRI scan disclosed an loss of hyperintense singnal of normal neurohypophysis and about 10 mm-sized nodular mass lesion on neurohypophysis. However, thickness of the pituitary stalk was normal. Pathologic examination demonstrated diffuse infiltration of lymphocytes and plasma cells. No adenomas, menigitis, sarcoidosis or granulomas were present. We supposed that this case was an atypical type of lymphocytic infundibuloneurohypophysitis, which did not belong to any other part of two groups described above.
