A case report of near-triploid in adult acute lymphocytic leukemia.
- Author:
Chong Ku JUN
1
;
Ju Young CHA
;
Hyung Mo OH
;
Yo Shik SHIN
;
Yun Kwon KIM
;
So Yon KIM
;
Young Jung KIM
;
Byung Yik PARK
;
Min Koo CHO
;
Gwon Jun LEE
;
Kyung In LEE
;
Eun Hee LEE
Author Information
1. Department of Internal Medicine, and Clinical Pathology, National Police Hospital, Seoul, Korea. bell939@hanmail.net
- Publication Type:Case Report
- Keywords:
Leukemia, Lymphocyte, Acute;
Chromosomal abnormality;
Chromosome 11
- MeSH:
Adult*;
Cell Count;
Chromosome Aberrations;
Chromosomes, Human, Pair 11;
Humans;
Karyotype;
Leukemia, B-Cell;
Leukemia, Lymphoid;
Male;
Precursor Cell Lymphoblastic Leukemia-Lymphoma*;
Prognosis;
Translocation, Genetic;
Triploidy
- From:Korean Journal of Medicine
2001;61(2):190-194
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In addition to age, white cell count and immunophenotype, karyotype has been reported to be one of the important prognostic factors in acute lymphocytic leukemias.Furthermore 70 percent of patients with acute B lymphocytic leukemia presented chromosomal abnormalities, which is known to have a close relationship with the prognosis. Among the abnormalities, triploid is rare and known to have the worse prognosis. Structural chromosomal abnormality of the 11q23 band is more common in childhood acute lymphocytic leukemia and has been rarely reported in adult lymphocytic leukemia. We present a case of a 29 year - old male patient with acute lymphocytic leukemia, who had triploid and chromosomal translocation including 11q23 band along with the review of related literature.
