Advances in the application of metabolomics technology in occupational health
10.20001/j.issn.2095-2619.20240819
- VernacularTitle:代谢组学技术在职业健康中的应用研究进展
- Author:
Zuofei XIE
1
;
Yiru QIN
;
Wenjie ZHANG
;
Lin ZHONG
;
Banghua WU
;
Weifeng RONG
Author Information
1. School of Public Health, Guangzhou Medical University, Guangzhou, Guangdong 511436, China
- Publication Type:Review
- Keywords:
Metabolomics;
Occupational health;
Occupational diseases;
Toxicological;
Biomarkers;
Research progress
- From:
China Occupational Medicine
2024;51(4):454-459
- CountryChina
- Language:Chinese
-
Abstract:
Metabolomics, including targeted metabolomics and non-targeted metabolomics, is a method to study endogenous small molecule metabolites in organisms. The process of metabolomics analysis generally includes sample collection and pre-treatment, sample detection, data preprocessing, metabolite identification, data statistical analysis, and others. At present, metabolomics technology has been applied to study toxicological mechanism of occupational hazards, early detection and diagnosis of occupational diseases, screening biomarkers of occupational exposure, and others. The application of metabolomics technology to explore the relationship between workers' metabolites and exposure to occupational hazardous, assess the potential impact of occupational exposure on workers' health, and search for ideal biomarkers or therapeutic targets is conducive to early warning and monitoring of occupational health hazards, and assistance in the early diagnosis and prognosis of occupational diseases.In the future, further research is needed in the field of occupational health using metabolomics to establish more complete and standardized workflows and experimental methods, combine big data technology to explore potential biomarkers, utilize metabolic information to provide precise occupational health services, and use artificial intelligence models for data mining and disease diagnosis in metabolomics.
