Analyzing the influencing factors of moderate-to-severe pulmonary ventilation dysfunction in patients with occupational pneumoconiosis complicated with pulmonary tuberculosis
10.20001/j.issn.2095-2619.20240812
- VernacularTitle:职业性尘肺病合并肺结核患者肺通气功能中重度损伤影响因素分析
- Author:
Jiuhong ZHANG
1
;
Zhixiong YANG
;
Huan NIE
;
Shaose YE
Author Information
1. Guangxi Zhuang Autonomous Region Center for Occupational Disease Prevention and Control, Nanning, Guangxi 530021, China
- Publication Type:Journal Article
- Keywords:
Pneumoconiosis;
Pulmonary tuberculosis;
Lung function;
Pulmonary infection;
Influencing factors
- From:
China Occupational Medicine
2024;51(4):419-423
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics and influencing factors of moderate-to-severe pulmonary ventilation dysfunction in occupational pneumoconiosis (hereinafter referred to as "pneumoconiosis") patients complicated with pulmonary tuberculosis. Methods A total of 136 male pneumoconiosis patients complicated with pulmonary tuberculosis suffering different degrees of pulmonary ventilation dysfunction were selected as the study subjects using the judgmental sampling method. Patients were divided into mild dysfunction and moderate-to-severe dysfunction groups based on the degrees of pulmonary ventilation dysfunction. Clinical data from patients of these two groups were collected, and influencing factors of pulmonary ventilation dysfunction were analyzed. Results The prevalence of mild dysfunction and moderate-to-severe dysfunction among the study subjects was 39.0% and 61.0%, respectively. The proportion of patients with moderate-to-severe pulmonary ventilation dysfunction increased with the progression of pneumoconiosis (P<0.05). Patients in moderate-to-severe dysfunction group had higher rates of dyspnea, elevated C-reactive protein, coexisting chronic obstructive pulmonary disease (COPD), and a history of lung infections within the past two years compared with those in the mild dysfunction group (all P<0.05). The result of multivariate logistic regression analysis showed that the degree of pneumoconiosis, complicated with COPD, and a history of lung infections within the past two years were risk factors for moderate-to-severe pulmonary ventilation dysfunction (all P<0.05). Specifically, higher degree of pneumoconiosis was associated with a greater proportion of moderate-to-severe dysfunction, and patients complicated with COPD or had a history of lung infections within the past two years were more likely to experience severe pulmonary ventilation dysfunction. Conclusion The degree of pneumoconiosis, complicated with COPD, and a history of lung infections within the past two years are influencing factors of moderate-to-severe pulmonary ventilation dysfunction in patients with pneumoconiosis combined with pulmonary tuberculosis. Early detection of pneumoconiosis progression, timely diagnosis of COPD and lung infections, and appropriate treatment such as antifibrotic agents, inhaled bronchodilators, and anti-infective therapies are recommended.
