Body Composition, Sarcopenia, and Serum Myokines in Acromegaly: A Narrative Review
10.11005/jbm.2024.31.3.182
- Author:
Arthur Costa INOJOSA
1
;
Ana Vitória Hirt RIBEIRO
;
Thaís Florêncio ARAÚJO
;
Maria Eduarda XAVIER
;
Daniella RÊGO
;
Francisco BANDEIRA
Author Information
1. Division of Endocrinology, Agamenon Magalhães Hospital, University of Pernambuco Medical School, Recife, Brazil
- Publication Type:Review Article
- From:Journal of Bone Metabolism
2024;31(3):182-195
- CountryRepublic of Korea
- Language:English
-
Abstract:
Patients with active acromegaly have a higher percentage of lean body mass, a lower percentage of fat body mass, and an increase in their extracellular water compartment compared to healthy individuals. However, muscle function appears to be compromised in patients with acromegaly, with some experiencing worsened physical performance and sarcopenia. Myokine alterations, insulin resistance, dysregulation of protein metabolism, muscle oxidative stress, neuromuscular junction impairment, and increased ectopic intramuscular fat deposits may play roles in muscle dysfunction in patients with acromegaly.
