Effect of Some Immunosuppressive Agents on the Survival of Experimental Skin Homografts in Rats I. Effect of Total Body Irradiation, Imuran, Prednisolone and Splenectomy.
- Author:
Won Suk KIM
;
Soo Duk LIM
;
Hong Sik KIM
- Publication Type:Original Article
- MeSH:
Allografts*;
Animals;
Azathioprine*;
Immunosuppressive Agents*;
Prednisolone*;
Rats*;
Skin*;
Splenectomy*;
Survival Rate;
Transplants;
Whole-Body Irradiation*
- From:Korean Journal of Dermatology
1970;8(1):3-9
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Several immunosuppressive agents were used to prolong the survival of full-thickries skin homografts in albino rats. The grafts were squares in size of 2.0cm. The results were as follows. 1. The mean survival time of skin homografts in control group was 6.0 days. 2. Total body X-irradiation (500r) to the recipients 24 hours before grafting resulted in prolongation of survival of the grafts. (Mean, 12.5 days) 3. Administration of Imuran(azathioprine) to the recipients in a does of 5mg/kg/day for 7 days. before grafting resulted in prolongation of survival of the grafts. (Mean, 9. 6 days) 4. Spleneetomized homografted rats showed no prolongation of survival of the grafts. (Mean, 6.1days) 5. Administration of prednisolone to the recipients in a does of 2mg/kg/day for 7 days before grafting resulted in no prolongation of survival of the grafts. (Mean, 6.3 days) 6. Above results were discussed and compared with those of others.
