A case of propylthiouracil-induced hepatitis with agranulocytosis.
- Author:
Jae Kyun LEE
1
;
Hong Ja KIM
;
Hwa Eun OH
Author Information
1. Department of Internal Medicine, Myong Ji Hospital Kwandong University College of Medicine, Koyang, Korea.
- Publication Type:Case Report
- Keywords:
Propylthiouracil;
Agranulocytosis;
Hepatitis
- MeSH:
Agranulocytosis*;
Exanthema;
Hepatitis*;
Humans;
Hyperthyroidism;
Leukopenia;
Liver Diseases;
Methimazole;
Prognosis;
Propylthiouracil
- From:Korean Journal of Medicine
2001;61(1):50-52
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hyperthyroidism is a common condition which is initially managed with an antithyroid drug, either propylthiouracil or methimazole. Adverse reactions occur in 1-5% of patients taking antithyroid medications, most commonly transient, benign leukopenia and skin rash. Agranulocytosis and liver dysfunction are reactions which occur infrequently. Severe hepatic toxicity combined with agranulocytosis has been known as rare complication. Experimental studies have demonstrated that immunological mechanisms play an important role. While most patients are completely recovered after stop of medication, some patients can show grave prognosis. We report a case of propylthiouracil induced hepatitis with agranulocytosis.
