Acute renal failure and delayed neuropathy due to anti-freeze ingestion.
- Author:
Su Jin YOON
1
;
Won Kyu CHANG
;
Myung Jun SONG
;
Nam Cheol HWANG
;
Su Jin LIM
;
Woon Hee PAIK
;
Yun Kwon KIM
;
So Yon KIM
;
Young Jung KIM
;
Byung Yik PARK
;
Min Koo CHO
;
Gwon Jun LEE
Author Information
1. Department of Internal Medicine, National Police Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Ethylene glycol;
Kidney failure, acute;
Neuropathy
- MeSH:
Acidosis;
Acute Kidney Injury*;
Brain;
Calcium Oxalate;
Eating*;
Ethylene Glycol;
Heart;
Incidence;
Kidney;
Korea;
Liver;
Nuclear Family;
Pancreas;
Poisoning
- From:Korean Journal of Medicine
2001;61(1):64-70
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Antifreeze contains ethylene glycol up to ninty five percent. Ethylene glycol is colorless, odorless, sweet-tasting and water-soluble compound and has been widely used as a chemical solvent. Ethylene glycol has been reported as a common cause of incidental poisoning all over the world because of its easy access. However, in Korea, it is not easy to find statistical references on incidences of ethylene glycol intoxication, except two reported cases. Ethylene glycol itself is not toxic substance. But, many other daughter metabolites are very toxic and lethal. Acid metabolites among them can cause metabolic acidosis. Oxalate, end-product of ethylene glycol, is quickly transformed to calcium oxalate crystals, which precipitate in body tissues such as brain, kidney, heart, liver, and pancreas. We report a case of acute renal failure and neuropathy due to ethylene glycol intoxication along with a review of toxic effects of ethylene glycol.
