Outcome of intradiscal condoliase injection therapy for patients with recurrent lumbar disc herniation
- Author:
Noritaka SUZUKI
1
;
Yawara EGUCHI
;
Takashi HIRAI
;
Takuya TAKAHASHI
;
Yohei TAKAHASHI
;
Kota WATANABE
;
Tomohiro BANNO
;
Kyohei SAKAKI
;
Satoshi MAKI
;
Yuuichi TAKANO
;
Yuki TANIGUCHI
;
Yasuchika AOKI
;
Takamitsu KONISHI
;
Yutaka HIRAIZUMI
;
Masatsune YAMAGATA
;
Akihiro HIRAKAWA
;
Seiji OHTORI
Author Information
- Publication Type:Clinical Study
- From:Asian Spine Journal 2024;18(4):550-559
- CountryRepublic of Korea
- Language:English
-
Abstract:
Methods:The study participants were 249 patients who underwent intradiscal condoliase injection for LDH at nine participating institutions, including 241 patients with initial LDH (group C) and eight with recurrent LDH (group R). Patient characteristics including age, sex, body mass index, disease duration, intervertebral LDH level, smoking history, and diabetes history were evaluated. Low back pain/leg pain Numerical Rating Scale (NRS) scores and the Oswestry Disability Index (ODI) were used to evaluate clinical symptoms before treatment and at 6 months and 1 year after treatment.
Results:Low back pain NRS scores (before treatment and at 6 months and 1 year after treatment, respectively) in group C (4.9 → 2.6 → 1.8) showed significant improvement until 1 year after treatment. Although a tendency for improvement was observed in group R (3.5 → 2.8 → 2.2), no significant difference was noted. Groups C (6.6 → 2.4 → 1.4) and R (7.0 → 3.1 → 3.2) showed significant improvement in the leg pain NRS scores after treatment. Group C (41.4 → 19.5 → 13.7) demonstrated significant improvement in the ODI up to 1 year after treatment; however, no significant difference was found in group R (35.7 → 31.7 → 26.4).
Conclusions:Although intradiscal condoliase injection is less effective for LDH recurrence than for initial cases, it is useful for improving leg pain and can be considered a minimally invasive and safe treatment method.
