Clinical Manifestation and Predisposing Factors of Infectious Keratitis Following Penetrating Keratoplasty in Korean Patients.
10.3341/jkos.2010.51.4.504
- Author:
Mijin KIM
1
;
Joo Youn OH
;
Mee Kum KIM
;
Sang Beom HAN
;
Jin Hak LEE
;
Won Ryang WEE
Author Information
1. Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. wrwee@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Cornea;
Infections;
Penetrating keratoplasty
- MeSH:
Bacteria;
Bacterial Infections;
Cornea;
Eye;
Glaucoma;
Graft Survival;
Humans;
Keratitis;
Keratoplasty, Penetrating;
Medical Records;
Retrospective Studies;
Transplants;
Treatment Outcome
- From:Journal of the Korean Ophthalmological Society
2010;51(4):504-509
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To report the clinical manifestation, predisposing factors, microbiological profiles and treatment outcome of infectious keratitis following penetrating keratoplasty (PK). METHODS: Medical records of the post-PK patients later diagnosed with culture-positive keratitis, between January 2003 and June 2008 at our hospital were retrospectively reviewed. RESULTS: Among 228 eyes of 226 patients who previously had PK, 18 eyes (7.89%) of 16 patients developed microbial keratitis. Fifteen patients had a bacterial infection, of which a Streprococcus species was the most common causative microorganism (6 eyes, 33.3%). Three eyes had fungal infection; one case was co-infected with bacteria. Six eyes (33.3%) presented with a suture-related problem, and sixteen eyes (88.9%) had been using topical glaucoma medications. The suture-related problem and use of glaucoma medication were significantly associated with the development of infectious keratitis (p=0.040 and 0.013, respectively). Remission was achieved in all cases within the mean duration of 2.47 months after treatment initiation. However, visual improvement was not achieved in 11 eyes (68.7%) due to graft opacity. CONCLUSIONS: Early identification of predisposing factors and appropriate management at an early stage may prevent the occurrence of graft infection and improve graft survival.
