Subacute Combined Degeneration Caused by Chronic Atrophic Gastritis with Spurious Elevation of Vitamin B12 Level.
- Author:
Jae Gun PARK
1
;
Hosun LEE
;
Min Su PARK
Author Information
- Publication Type:Case Report
- Keywords: Subacute combined denegenration; Methylmalonic acid; Homocysteine
- MeSH: Delayed Diagnosis; Gastritis, Atrophic*; Homocysteine; Humans; Methylmalonic Acid; Nervous System; Subacute Combined Degeneration*; Vitamin B 12 Deficiency; Vitamin B 12*; Vitamins*
- From:Journal of the Korean Neurological Association 2017;35(1):22-25
- CountryRepublic of Korea
- Language:Korean
- Abstract: We report a patient who was diagnosed as subacute combined degeneration (SCD) with elevated homocysteine and methylmalonic acid levels in the situation of a spurious elevation of the vitamin B12 concentration. A false-positive elevation of the vitamin B12 level could lead to a delayed diagnosis and cause irreversible changes in the nervous systems. We therefore suggest that the homocysteine and methylmalonic acid levels should be checked in patients with a normal or elevated vitamin B12 level for whom there is a high clinical suspicion for vitamin B12 deficiency, as a further evaluation for SCD.
