Correlation of Radiologic and Pathologic Lymph Non Involvement with TIMP-2 ( tissue inhibitors of metalloproteinase-2 ) in Gastric and Colon Carcinomas.
- Author:
Soo Youn HAM
1
;
Jong Hwa LEE
;
Byung Kyun KO
;
Hong Rae CHO
;
Dae Wha CHOI
;
Chang Woo NAM
;
Sung Sook KIM
;
Woon Sup HAN
;
Min Young KIM
Author Information
1. Department of Radiology, Ulsan University Hospital, Korea.
- Publication Type:Original Article
- Keywords:
TIMP-2;
Stomach neoplasm;
Colon neoplasm;
CT
- MeSH:
Colon*;
Colonic Neoplasms;
Humans;
Lymph Nodes;
Prognosis;
Stomach;
Stomach Neoplasms;
Tissue Inhibitor of Metalloproteinase-2*;
Tomography, X-Ray Computed
- From:Journal of the Korean Cancer Association
1999;31(1):9-15
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the correlation between the expression of TIMP-2 (tissue inhibitors of metalloproteinase-2) and negative lymph node involvement of colon and gastric carcinoma. MATERIALS AND METHODS: We studied 26 cases (13 each) of gastric and colon carcinoma specimens along with dissected lymph nodes by immunohistochemical staining to investigate the correlation of the expression of TIMP-2. Lymph nodes involvement by CT scan was defined by size criteria and the presence of central low density. RESULTS: Eight cases with positive lymph node involvement by CT scan showed weak expression of TIMP-2. Ten cases with positive lymph node involvement had weak expression of TIMP-2. Among eight cases with strong expression of TIMP-2 7 patients were negative by radiologic exam. Good correlation between strong TIMP-2 expression and negative lymph node involvement by CT scan was found (<0.05). CONCLUSION: As the expression of TIMP-2 had a good correlation with radiologic involvement of lymph nodes, the study of expression of TIMP-2 in patients with stomach and colon carcinoma might be helpful in planning surgery and predicting the prognosis.
