Protracted Venous Infusion of 5-Fluorouracil as a Chemotherapy in Colorectal Cancer.
- Author:
Hyun Sik JEONG
;
Won Seog KIM
;
Sook In JUNG
;
Jong Tae LEE
;
Ki Hyun KIM
;
Sung Soo YOON
;
Won Ki KANG
;
Hong Ghi LEE
;
Ken Chil PARK
;
Poong Lyul RHEE
;
Hae Jun KIM
;
Ho Kyun CHUN
;
Chan Hyung PARK
- Publication Type:Original Article
- Keywords:
Colorectal cancer;
Protracted infusion;
Salvage chemotherapy
- MeSH:
Colorectal Neoplasms*;
Disease Progression;
Drug Therapy*;
Fluorouracil*;
Hand-Foot Syndrome;
Humans;
Infusion Pumps;
Infusions, Intravenous;
Leucovorin;
Stomatitis
- From:Journal of the Korean Cancer Association
1999;31(1):120-125
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The administration of 5-fluorouracil (5-FU) by protracted intravenous infusion is an alternative to the bolus administration of 5-FU in patients with advanced colorectal cancers. This study was performed to evaluate the response rate and toxicities of protracted infusion of 5-FU in patients with advanced or recurrent colorectal cancers who had been treated with 5-FU by bolus or shortterm continuous administration. MATERIALS AND METHODS: Between March 1995 and June 1997, twenty-eight patients with advanced colorectal cancer previously exposed to 5-FU based chemotherapy were enrolled in this triaL Patients received 5-FU (250 mg/m(2)/day days 1-28) or 5-FU plus leucovorin (5-FU; 200 mg/m/day days 1-28, leucovorin; 20 mg/m IV days 1, 8, 15, 21) by ambulatory infusion pump. Treatment course was repeated every 42 days until disease progression. RESULT: Twenty-eight patients entered. All 28 patients were assessable for response and toxicity. Five (19%) patients achieved a partial response, with the median response duration of 15 weeks (range; 7-22 weeks), and median survival time of entire patients was 54 weeks (range 7-151+ weeks). Gastrointestinal toxicity, specifically stomatitis was a major toxicity (grade 2, 12%; grade 3, 4%), but hand-foot syndrome was less frequent (5%) compared with other trials with protracted infusion of 5-FU reported in the literature. Hematologic toxicity was generally of low grade. CONCLUSION: Prolonged intravenous infusion of 5-FU can produce a response rate of 19% with low toxicity among patients refractory to bolus or short-term infusion of S-FU.
