A Case of Angiosarcoma Associated with Adjuvant Radiotherapy in a Patient with Breast Cancer
- Author:
Yeounkuk SUNG
1
;
Aram KIM
;
Kyung Eun JUNG
;
Young LEE
;
Young Joon SEO
;
Dongkyun HONG
Author Information
1. Departments of Dermatology, Chungnam National University School of Medicine, Daejeon, Korea
- Publication Type:Case Report
- From:Korean Journal of Dermatology
2024;62(7):418-421
- CountryRepublic of Korea
- Language:English
-
Abstract:
Angiosarcoma is a rare yet aggressive tumor that originates from endothelial cells lining the blood or lymphatic vessels. Angiosarcoma is commonly associated with radiotherapy, often developing as a secondary cancer following irradiation. In this report, we present a case of a 66-year-old woman who underwent a lumpectomy with adjuvant radiotherapy for left breast cancer 9 years ago. She was referred to our clinic due to erythematous nodules and papules on the left breast that developed 10 months prior. A cutaneous biopsy revealed irregular, anastomosing vessels lined by crowded swollen endothelial cells, exhibiting nuclear atypia. The immunohistochemical stains for alpha-smooth muscle actin and CD31 were positive, while the ki-67 index was elevated. However, the stain was negative for human herpesvirus 8. Clinical and histopathological features were consistent with angiosarcoma associated with adjuvant radiotherapy. The patient underwent a left total mastectomy with sentinel lymph node biopsy. However, 18 months later, multiple bone metastases were noted on positron emission tomography-computed tomography, and the patient received palliative radiotherapy and supportive care.
