Effects of the C3G/D3G anthocyanins-rich black soybean testa extracts on improvement of lipid profiles in STZ-induced diabetic rats.
10.4163/jnh.2015.48.4.299
- Author:
So Young PARK
1
;
Sujeong PAK
;
Song Joo KANG
;
Na Young KIM
;
Da Saem KIM
;
Min Jin KIM
;
Seon Ah KIM
;
Ji Young KIM
;
So Yeon PARK
;
So Hyun PARK
;
Cho Rong YOUN
;
Bo Ram LEE
;
Hyo Eun LEE
;
So Young CHOI
;
Hee Won CHOI
;
Jin Yeo HEO
;
A Yeong HWANG
;
Myoung Sook LEE
Author Information
1. Research Institute of Obesity Science, Sungshin Women's University, Seoul 142-732, Korea. mlee@sungshin.ac.kr
- Publication Type:Original Article
- Keywords:
anthocyanin;
black soybean testa;
lipid profiles;
streptozotocin;
diabetes
- MeSH:
Animals;
Anthocyanins;
Blood Glucose;
Cholesterol;
Glucose Transport Proteins, Facilitative;
Hypercholesterolemia;
Hyperlipidemias;
Insulin;
Liver;
Muscle, Skeletal;
Oxidoreductases;
Rats*;
Soybeans*;
Streptozocin;
Triglycerides
- From:Journal of Nutrition and Health
2015;48(4):299-309
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The purpose of this study was to examine the effect of black soybean (CJ-3) testa extracts on lipid profiles in streptozotocin (STZ)-induced diabetic rats. METHODS: One control group and four STZ-induced diabetic groups with different doses of black soybean (CJ-3) testa extracts treatment [0 mg/kg (diabetic control, EX), 250 mg/kg (EX-250), 500 mg/kg (EX-500), 1,000 mg/kg (EX-1000)] were orally administered for 4 weeks. RESULTS: All CJ-3 treatment groups had remarkably lower serum triglyceride (TG) levels than that of EX group (p < 0.05) whereas hepatic TG contents did not show any differences. Results from serum total cholesterol (TC) concentrations of EX-250 and EX-1000 groups were decreased compared to EX group (p < 0.05). Furthermore, protein levels of 3-hydroxy-3-methyl-glutaryl-Coenzyme A (HMG-CoA) reductase from the liver decreased in all treatment groups (p < 0.05). However, significant differences were not observed in serum glucose and insulin, and glucose transporter 4 (GLUT-4) protein expression in skeletal muscle tissue. CONCLUSION: These results suggest that black soybean testa extracts could be useful for improvement of hyperlipidemia and hypercholesteremia in diabetes.
