Dual-Isotope SPECT Imaging with Thallium-201 and Technetium-99m MIBI in Detecting Coronary Artery Disease.
10.12701/yujm.1999.16.1.101
- Author:
Gyu Gwang LEE
1
;
Ihn Ho CHO
;
Hyoung Woo LEE
;
Jong Sun PARK
;
Kyu Chang WON
;
Dong Gu SIN
;
Young Jo KIM
;
Bong Sup SHIM
Author Information
1. Department of Nuclear Medicine College of Medicine, Yeungnam University, Taegu, Korea.
- Publication Type:Original Article
- Keywords:
Tc-99m MIBI;
Tl-201;
Dual-isotope imaging
- MeSH:
Coronary Angiography;
Coronary Artery Disease*;
Coronary Vessels*;
Dipyridamole;
Humans;
Tomography, Emission-Computed, Single-Photon*
- From:Yeungnam University Journal of Medicine
1999;16(1):101-107
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We evaluated the results of sequential SPECT dual-isotope imaging with Tl-201 and Tc-99m MIBI in 24 patients, all of whom also had coronary angiography within the past one month. Coronary angiography showed that 12 patients had no CAD, 4 patients had one-vessel CAD, 7 patients had two-vessel CAD and 1 patient had three-vessel CAD. Serial studies of resting Tl-201 and dipyridamole stress Tc-99m MIBI were completed within 2 hours. When more then 50% of coronary artery narrowing was considered significant. The overall sensitivity and specification of CAD detection were 91.7%. The sensitivity of CAD detection in patients with one-vessel and multi-vessel diseases was 75% and 100%, respectively. Therefore, sequential dual-isotope SPECT demonstrated high sensitivity and specificity of CAD detection. In conclusion, sequential dual-isotope imaging is feasible and can be completed in a short time and may therefore enhance laboratory throughput and patient convenience.
