Different development patterns of reward behaviors induced by ketamine and JWH-018 in striatal GAD67 knockdown mice
- Author:
Sun Mi GU
1
;
Eunchong HONG
;
Sowoon SEO
;
Sanghyeon KIM
;
Seong Shoon YOON
;
Hye Jin CHA
;
Jaesuk YUN
Author Information
- Publication Type:Research Report
- From:Journal of Veterinary Science 2024;25(5):e63-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objective:The study was designed to examine the effects of the downregulation of GAD67 expression in the dorsal striatum on reward behavior development.
Methods:We evaluated the effects of GAD67 knockdown on depression-like behavior and anxiety using the forced swim test and elevated plus maze test in a mouse model. We further determined the effects of GAD67 knockdown on ketamine- and JWH-018-induced conditioned place preference (CPP).
Results:Knockdown of GAD67 in the dorsal striatum of mice increased depression-like behavior, but it decreased anxiety. Moreover, the CPP score on the NMDA receptor antagonist ketamine was increased by GAD67 knockdown, whereas the administration of JWH-018, a cannabinoid receptor agonist, did not affect the CPP score in the GAD67 knockdown mice group compared with the control group.
Conclusions:and Relevance: These results suggest that striatal GAD67 reduces GABAergic neuronal activity and may cause ketamine-induced NMDA receptor inhibition. Consequently, GAD67 downregulation induces vulnerability to the drug reward behavior of ketamine.
