Urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion before and during cisplatin chemotherapy in patients with intrathoracic malignancy.
10.4046/trd.1999.46.6.811
- Author:
Dong Gyoo YANG
1
;
Yoon Soo CHANG
;
Young Sam KIM
;
Jun Gu LEE
;
Kang Hyun AHN
;
Jae Min PARK
;
Se Kyu KIM
;
Hyun Cheol CHUNG
;
Joon CHANG
;
Chul Min AHN
;
Sung Kyu KIM
;
Won Young LEE
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Nausea and vomiting;
Serotonin;
Urinary 5-HIAA;
Cisplatin chemotherapy
- MeSH:
Cisplatin*;
Drug Therapy*;
Enterochromaffin Cells;
Female;
Humans;
Hydroxyindoleacetic Acid;
Male;
Nausea;
Ondansetron;
Plasma;
Receptors, Serotonin, 5-HT3;
Serotonin;
Vomiting
- From:Tuberculosis and Respiratory Diseases
1999;46(6):811-816
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Nausea and vomiting associated with chemotherapy are common side effects which remain difficult to control. Acute phase nausea and vomiting (0-24 hours after induction of chemotherapy) parallels plasma serotonin release, which explains the effectiveness of 5-HT3 receptor antagonists. Serotonin released from gastrointestinal enterochromaffin cells may mediate chemotherapy-induced emesis. In this study, we analyzed urinary excretion of 5-HIAA, the main metabolite of serotonin. METHODS: Eight men and four women were studied in their cisplatin chemotherapy cycle. Urinary 5-hydroxyindoleacetic aicd (HIAA) levels were determined before and during a 24-hour period under ondansetron prophylaxis. RESULTS: Urinary 5-HIAA excretion for a 24-hour period was increased in all patients after induction of cisplatin (P=0.002). CONCLUSION: Cisplatin chemotherapy is associated with serotonin release in the acute phase. Our finding provides evidence for a relationship between emesis and serotonin following cisplatin chemotherapy.
