No Association of Vascular Endothelial Growth Factor-A (VEGF-A) and VEGF-C Expression with Survival in Patients with Gastric Cancer.
- Author:
Soo Jung LEE
1
;
Jong Gwang KIM
;
Sang Kyun SOHN
;
Yee Soo CHAE
;
Joon Ho MOON
;
Shi Nae KIM
;
Han Ik BAE
;
Ho Young CHUNG
;
Wansik YU
Author Information
1. Department of Oncology/Hematology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea. jkk21c@knu.ac.kr
- Publication Type:Original Article
- Keywords:
Stomach neoplasms;
VEGF-A;
Prognosis
- MeSH:
Adenocarcinoma;
Formaldehyde;
Humans;
Multivariate Analysis;
Paraffin;
Prognosis;
Stomach Neoplasms;
Vascular Endothelial Growth Factor A;
Vascular Endothelial Growth Factor C
- From:Cancer Research and Treatment
2009;41(4):218-223
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Although the vascular endothelial growth factor (VEGF) superfamily has been identified to critically influence tumor-related angiogenesis, the prognostic significance of a VEGF expression in gastric cancer is still controversial. Accordingly, the present study analyzed the VEGF-A and VEGF-C expressions and their impact on the prognosis of patients with gastric cancer. MATERIALS AND METHODS: Three hundred seventy-five consecutive patients who underwent surgical resection for gastric adenocarcinoma with a curative intent were enrolled in the present study. Immunohistochemical staining for VEGF-A and VEGF-C was performed using the formalin fixed, paraffin embedded tumor tissues. RESULTS: Positive VEGF-A and VEGF-C expressions were observed in 337 (90.1%) and 278 (74.9%) cases, respectively. The survival analysis showed that the expression of VEGF-A and VEGF-C had no effect on the OS and DFS. On the multivariate analysis that included age, gender and the TNM stage, no significant association between the grade of the VEGF-A or VEGF-C expression and survival was observed. CONCLUSION: The current study suggests that the tissue expression of VEGF-A or VEGF-C alone is not an independent prognostic marker for patients with surgically resected gastric adenocarcinoma.
