Mixed Testicular Germ Cell Tumor Presenting as Metastatic Pure Choriocarcinoma Involving Multiple Lung Metastases That Was Effectively Treated with High-dose Chemotherapy.
- Author:
Sang Cheol LEE
1
;
Kyoung Ha KIM
;
Sung Han KIM
;
Nam Su LEE
;
Hee Sook PARK
;
Jong Ho WON
Author Information
1. Division of Hematology-Oncology, Department of Internal Medicine, Soonchunhyang University Hospital, Seoul, Korea. jhwon@hosp.sch.ac.kr
- Publication Type:Case Report
- Keywords:
Neoplasms;
Germ cell and embryonal;
Testicular choriocarcinoma;
High-dose chemotherapy
- MeSH:
Choriocarcinoma;
Drug Therapy, Combination;
Etoposide;
Female;
Germ Cells;
Humans;
Lung;
Neoplasm Metastasis;
Neoplasms, Germ Cell and Embryonal;
Pregnancy;
Stem Cells;
Testicular Neoplasms;
Testis
- From:Cancer Research and Treatment
2009;41(4):229-232
- CountryRepublic of Korea
- Language:English
-
Abstract:
Choriocarcinoma in the testis is very rare, and it represents less than 1% (0.3%) of all the testicular germ cell tumors. It is a particularly aggressive variant of non-seminoma tumor, which is characterized by a high serum beta-HCG level and multiple lung metastases. The optimal management for this disease remains undefined. We report here on a case of choriocarcinoma with multiple lung metastases, and the patient has achieved continuous remission for 2 years after combination chemotherapy of BEP (bleomycin, etoposide and cisplatin) and sequential high-dose chemotherapy with autologous peripheral stem cell rescue.