A Case of Intertriginous Granular Parakeratosis.
- Author:
Young Eun CHO
1
;
Seong Hyun KIM
;
Yoo Won CHOI
;
Hae Young CHOI
;
Ki Bum MYUNG
Author Information
1. Department of Dermatology, College of Medicine, Ewha Womans University Seoul, Korea. kbmyung@mm.ewha.ac.kr
- Publication Type:Case Report
- Keywords:
Intertriginous granular parakeratosis;
Keratohyaline granule
- MeSH:
Axilla;
Dermis;
Epidermis;
Groin;
Humans;
Middle Aged;
Parakeratosis*
- From:Korean Journal of Dermatology
2001;39(9):1003-1005
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Intertriginous granular parakeratosis is a condition presenting with erythematous hyperkeratotic papules and plaques localized to the intertriginous areas such as axilla, groin and perianal area. Although the etiology of granular parakeratosis remains obscure, it is probably caused by a defect in conversion of profilaggrin to filaggrin. The defect results in a failure to degrade keratohyaline granules and to aggregate keratin filaments during cornification. We report a 59-year-old man who presented with erythematous fissured patches on the perianal area for 1 year. Histopathologic examination revealed mild acanthosis and severe parakeratosis with prominent keratohyaline granules in the epidermis and vascular proliferation and RBC extravasation in the dermis.
