Synthesis and biological effects of some isatine derivatives
- Author:
Dat Quang Nguyen
- Publication Type:Journal Article
- Keywords:
isatine
- MeSH:
isatinecic acid;
analogs & derivatives
- From:Pharmaceutical Journal
2001;298(2):8-10
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Nitration of isatin gives 5-nitroisatin (I). On boiling (I) with 5% formaldehyde solution for short periods of time, a compound was isolated which has been characterized as N-hydroxymethyl-5-nitroisatin (II). By the condensation of I (and II) with various H2N-B compounds, 17 derivatives (III-XIX) were formed. The structures of the obtained products were characterized by elemental analysis and IR spectroscopy. The synthesized compounds were tested for biological activities such as antibacterial activity on 9 strains of bacteria
