Superoxide Dismutase Gene (SOD1, SOD2, and SOD3) Polymorphisms and Antituberculosis Drug-induced Hepatitis.
- Author:
Sang Hoon KIM
1
;
Sang Heon KIM
;
Jae Hyoung LEE
;
Byoung Hoon LEE
;
Ho Joo YOON
;
Dong Ho SHIN
;
Sung Soo PARK
;
Suk Bin JANG
;
Jae Seuk PARK
;
Young Koo JEE
Author Information
- Publication Type:Brief Communication
- Keywords: Antituberculosis drugs; hepatitis; superoxide dismutase; polymorphism
- MeSH: Alleles; Drug-Induced Liver Injury*; Genotype; Hepatitis; Humans; Introns; Korea; Polymorphism, Single Nucleotide; Risk Factors; Superoxide Dismutase*
- From:Allergy, Asthma & Immunology Research 2015;7(1):88-91
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: Drug-induced liver injury (DILI) is a serious issue often leading to discontinuation of the proper regimen of antituberculosis drugs (ATD). Previous studies have suggested that antioxidant enzymes play an important role in DILI. METHODS: We explored whether polymorphisms in superoxide dismutase genes, including Cu/Zn superoxide dismutase (SOD1), manganese superoxide dismutase (SOD2) and extracellular superoxide dismutase (SOD3) are associated with ATD-induced hepatitis. Genotype distributions of four single nucleotide polymorphisms (SNPs) in three genes (rs2070424, SOD1; rs4880, SOD2; rs2536512, and rs1799895, SOD3) were compared between 84 patients with ATD-induced hepatitis and 237 patients tolerant to ATD. RESULTS: Intron SNP rs2070424 of SOD1 showed a significant association with ATD-induced hepatitis. The frequency of genotypes carrying minor alleles (GA or GG) was significantly higher in the case group than that of controls (P=0.019, OR=2.26, 95% CI 1.14-4.49). For the other SNPs of SOD2 and SOD3, there were no differences in genotype frequencies between ATD-induced hepatitis and ATD-tolerant controls. CONCLUSIONS: These findings suggest that rs2070424 of SOD1 is significantly associated with ATD-induced hepatitis. This genetic variant may be a risk factor for ATD-induced hepatitis in individuals from Korea.
