Epigenetics: general characteristics and implications for oral health.
- Author:
Ji Yun SEO
1
;
Yoon Jung PARK
;
Young Ah YI
;
Ji Yun HWANG
;
In Bog LEE
;
Byeong Hoon CHO
;
Ho Hyun SON
;
Deog Gyu SEO
Author Information
- Publication Type:Review
- Keywords: Dental pulp cell; Epigenetic mechanism; Epigenetics; Gene regulation; Periodontitis
- MeSH: Base Sequence; Biology; Dental Research; Dentistry; DNA Methylation; Epigenomics*; Gene Expression; Histones; Oral Health*; Periodontitis; RNA, Untranslated; Tooth
- From:Restorative Dentistry & Endodontics 2015;40(1):14-22
- CountryRepublic of Korea
- Language:English
- Abstract: Genetic information such as DNA sequences has been limited to fully explain mechanisms of gene regulation and disease process. Epigenetic mechanisms, which include DNA methylation, histone modification and non-coding RNAs, can regulate gene expression and affect progression of disease. Although studies focused on epigenetics are being actively investigated in the field of medicine and biology, epigenetics in dental research is at the early stages. However, studies on epigenetics in dentistry deserve attention because epigenetic mechanisms play important roles in gene expression during tooth development and may affect oral diseases. In addition, understanding of epigenetic alteration is important for developing new therapeutic methods. This review article aims to outline the general features of epigenetic mechanisms and describe its future implications in the field of dentistry.
