Evaluation of Silicone-Based Gel for the Treatment of Hypertrophic Scarring in Rat Models
- Author:
So-Jeong YIM
1
;
Da-Ye NAM
;
Da-Hye CHOI
;
Jin WOO
;
Youngtae KIM
;
JungHoon CHAE
;
Young-Shin LEE
;
Ji-Youl JUNG
Author Information
- Publication Type:Original Article
- From: Journal of Wound Management and Research 2024;20(2):122-127
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:Hypertrophic scarring represents an aberrant response to wounds in certain individuals, manifesting with symptoms such as itching, tenderness, pain, and pigmentation. This study aimed to investigate the impact of a silicone-based gel on the healing of hypertrophic scars, particularly those originating from deep tissue wounds.
Methods:A rat model of wound healing and scarring was established, and 12 rats were randomly assigned to three groups: Dermatix Ultra group, SFG-100 silicone-gel group, and non-treated group. Rats in the treated groups (Dermatix Ultra and SFG-100 silicone-gel) received twice-daily applications for 8 weeks. Histologic analysis, including biopsy, was conducted to evaluate the scar elevation index, epidermis thickness, and the number of granulation veins.
Results:Overall, both the Dermatix Ultra and SFG-100 silicone-gel groups exhibited improvements in hypertrophic scar healing, accompanied by a significant reduction in skin pigmentation. Histopathologically, scars in both treated groups displayed a notable decrease in scar elevation index, epithelial thickness, and collagen disorganization compared to the non-treated group. However, no significant difference was observed between the Dermatix Ultra and SFG-100 silicone-gel groups.
Conclusion:The results suggest that SFG-100 silicone-gel is an effective therapeutic agent for hypertrophic scars. Further research is warranted to elucidate the mechanisms underlying its efficacy and to optimize its application for clinical use.
