Intravascular schwannoma as an extremely unusual cause of vein obstruction: a case report
- Author:
Luis Miguel CHINCHILLA-TÁBORA
1
;
Beatriz Segovia BLÁZQUEZ
;
José María SAYAGUÉS
;
Marta Rodríguez GONZÁLEZ
;
Joaquín GONZÁLEZ-RIVERO
;
José Antonio Muñoz LEÓN
;
Andrea Beatriz Jiménez PÉREZ
;
Idalia González MORAIS
;
Diego BUENO-SACRISTÁN
;
María Dolores LUDEÑA
Author Information
- Publication Type:Case Study
- From:Journal of Pathology and Translational Medicine 2024;58(5):249-254
- CountryRepublic of Korea
- Language:English
- Abstract: The blood vessel lumen is an extremely rare location for a benign peripheral nerve sheath tumor like schwannoma. Less than 10 cases have been previously reported. In this report, we present a case of a 68-year-old woman who had a soft tissue nodule at the posterior calf of her left leg during a physical examination. Pathological examination was performed after complete surgical excision. The patient underwent follow-up for 12 months after surgery without evidence of recurrence or any other complication. This is the first case of intravascular schwannoma reported as a cause of vein obstruction. Microscopically, the tumor was composed of Schwann spindle cells that were immunoreactive for S100 protein and SOX10. This tumor was surrounded by a well-defined vascular smooth muscle wall. Prospective series are required to improve the knowledge on the underlying mechanisms of intravascular schwannoma development.
