A Case of Amantadine-Induced Corneal Edema.
10.3341/jkos.2009.50.6.936
- Author:
Bo Sung HWANG
1
;
Sang Bumm LEE
;
Soon Cheol CHA
;
Won Ryang WEE
Author Information
1. Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Korea. sbummlee@med.yu.ac.kr
- Publication Type:Case Report
- Keywords:
Amantadine;
Corneal edema;
Corneal endothelium;
Parkinsonism
- MeSH:
Adult;
Amantadine;
Corneal Edema;
Corneal Ulcer;
Edema;
Endothelium, Corneal;
Eye;
Fluorometholone;
Follow-Up Studies;
Humans;
Hypoxia, Brain;
Parkinsonian Disorders;
Ventricular Fibrillation;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
2009;50(6):936-941
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To report a rare case of corneal edema caused by amantadine. CASE SUMMARY: A 35-year-old man was diagnosed with hypoxic brain damage caused by ventricular fibrillation. The patient showed Parkinsonism and was started on treatment with amantadine. Thirty-seven months after the commencement of amantadine treatment, the patient suffered a corneal ulcer in his right eye, which healed with opacity and thinning after medical treatment. After healing, slit-lamp examination revealed a bilateral, epithelial and stromal edema without obvious guttae and keratic precipitates. The corneal edema did not improve with topical treatment of 5% NaCl and 0.02% fluorometholone in both eyes. Three months after leaving the hospital, the patient's corrected visual acuity decreased to 0.2 (-2.0 Dsph -0.5 Dcyl Ax 90) in the right eye and 0.4 (-0.75 Dsph -2.0 Dcyl Ax 90) in the left eye. Amantadine medication was discontinued after discussion with the patient's neurologist. At the 1-month follow-up, corneal examination revealed resolution of the epithelial and stromal edema in both eyes. Corrected visual acuity was improved to 0.5 (-1.5 Dsph) in the right eye and 0.7 (-1.0 Dsph -1.0 Dcyl Ax 90) in the left eye. CONCLUSIONS: In cases of corneal edema without an obvious causative disease, the patient's systemic medication list must be reviewed and amantadine should be considered as a possible cause.
