Phosphorylated Tau in the Taste Buds of Alzheimer’s Disease Mouse Models
- Author:
Hyun Ji KIM
1
;
Bo Hye KIM
;
Dong Kyu KIM
;
Hanbin KIM
;
Sang-Hyun CHOI
;
Dong-Hoon KIM
;
Myunghwan CHOI
;
Inhee MOOK-JUNG
;
Yong Taek JEONG
;
Obin KWON
Author Information
- Publication Type:Original Article
- From:Experimental Neurobiology 2024;33(4):202-214
- CountryRepublic of Korea
- Language:English
- Abstract: Numerous systemic diseases manifest with oral symptoms and signs. The molecular diagnosis of Alzheimer’s disease (AD), the most prevalent neurodegenerative disease worldwide, currently relies on invasive or expensive methods, emphasizing the imperative for easily accessible biomarkers.In this study, we explored the expression patterns of key proteins implicated in AD pathophysiology within the taste buds of mice. We detected the expression of amyloid precursor protein (APP) and tau protein in the taste buds of normal C57BL/6 mice. Phosphorylated tau was predominantly found in type II and III taste cells, while APP was located in type I taste cells. Remarkably, we observed significantly stronger immunoreactivity to phosphorylated tau in the taste buds of aged AD mouse models compared to age-matched controls. These findings underscore the oral expression of biomarkers associated with AD, highlighting the diagnostic potential of the oral cavity for neurodegenerative diseases.
