Cox-2 and IL-10 Polymorphisms and Association with Squamous Cell Carcinoma of The Head and Neck in a Korean Sample.
10.3346/jkms.2010.25.7.1024
- Author:
Seung Won JEONG
1
;
Kyung TAE
;
Seung Hwan LEE
;
Kyung Rae KIM
;
Chul Won PARK
;
Byung Lae PARK
;
Hyoung Doo SHIN
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Hanyang University, Seoul, Korea. kytae@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Carcinom, Squamous Cell;
Head and Neck Neoplasms;
Cyclooxygenase 2;
Interleukin-10;
Polymorphism, Genetic;
Polymorphism, Single Nucleotide
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Asian Continental Ancestry Group/*genetics;
Carcinoma, Squamous Cell/*genetics;
Cyclooxygenase 2/*genetics;
Female;
*Genetic Predisposition to Disease;
Genotype;
Haplotypes;
Head and Neck Neoplasms/*genetics;
Humans;
Interleukin-10/*genetics;
Korea;
Male;
Middle Aged;
*Polymorphism, Genetic;
Risk Factors
- From:Journal of Korean Medical Science
2010;25(7):1024-1028
- CountryRepublic of Korea
- Language:English
-
Abstract:
Cyclooxygenase-2 (COX-2) is involved in inflammation and carcinogenesis. Interleukin-10 (IL-10) is also regarded as anti-inflammatory factors with the multi-functional ability to positively and negatively influence functional immunity and tumor development. Genetic polymorphisms of COX-2 and IL-10 might contribute to the development of squamous cell carcinoma of the head and neck (SCCHN). The purpose of this study was to evaluate the association of COX-2 and IL-10 single nucleotide polymorphisms (SNPs) with the risk of SCCHN in a Korean sample. We analyzed the COX-2 SNPs, -1329A>G, +1266C>T, and +6365T>C, and the IL-10 SNPs, -1082A>G, +920T>G, and +3917T>C, in 290 Korean SCCHN patients and 358 healthy controls. There was no significant association between the risk of SCCHN and the three COX-2 or three IL-10 SNPs. We analyzed three haplotypes (ht1, ht2, ht3) for COX-2 and found that COX-2 ht3+/+ was associated with a decreased risk of SCCHN in a Korean sample, compared with the COX-2 ht3 -/- genotype (P=0.03). Two haplotypes (ht1, ht2) of IL-10 were analyzed and there was no statistical significance in the distribution of haplotypes. Based on these results, the COX-2 haplotype ht3 can be used as a molecular biomarker to predict low risk groups of SCCHN in a Korean sample.
