Carnosine and Retinol Synergistically Inhibit UVB-Induced PGE2Synthesis in Human Keratinocytes through the Up-Regulation of Hyaluronan Synthase 2
10.4062/biomolther.2023.226
- Author:
In Guk PARK
1
;
Sun Hee JIN
;
Seungchan AN
;
Min Won KI
;
Won Seok PARK
;
Hyoung-June KIM
;
Yongjoo NA
;
Minsoo NOH
Author Information
1. Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea
- Publication Type:Original Article
- From:Biomolecules & Therapeutics
2024;32(5):635-639
- CountryRepublic of Korea
- Language:English
-
Abstract:
Skin aging results from complex interactions of intrinsic and extrinsic factors, leading to structural and biochemical changes such as wrinkles and dryness. Ultraviolet (UV) irradiation leads to the degradation of hyaluronic acid (HA) in the skin, and the fragmented HA contributes to inflammation. This study revealed that the synergistic combination of carnosine and retinol (ROL) increases HA production in normal human epidermal keratinocytes (NHEKs) by upregulating hyaluronan synthase 2 (HAS2) gene transcription. Simultaneously, the combined treatment of carnosine and ROL significantly attenuates UVB-induced prostaglandin E2 (PGE2) synthesis in NHEKs. A significant correlation exists between the increase of HA synthesis and the inhibition of PGE2 production. This study suggests that combined treatment of carnosine and ROL can improve skin aging phenotypes associated with UVB irradiation.
