Eligibility for Statin Treatment in Korean Subjects with Reduced Renal Function: An Observational Study.
10.3803/EnM.2016.31.3.402
- Author:
Byung Sub MOON
1
;
Jongho KIM
;
Ji Hyun KIM
;
Young Youl HYUN
;
Se Eun PARK
;
Hyung Geun OH
;
Cheol Young PARK
;
Won Young LEE
;
Ki Won OH
;
Kyu Beck LEE
;
Hyang KIM
;
Sung Woo PARK
;
Eun Jung RHEE
Author Information
1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. hongsiri@hanmail.net
- Publication Type:Original Article
- Keywords:
Renal insufficiency, chronic;
Cholesterol guidelines;
Statin
- MeSH:
Adenosine Triphosphate;
Adult;
Cardiology;
Cardiovascular Diseases;
Cohort Studies;
Glomerular Filtration Rate;
Heart;
Humans;
Hydroxymethylglutaryl-CoA Reductase Inhibitors*;
Kidney Diseases;
Observational Study*;
Renal Insufficiency, Chronic
- From:Endocrinology and Metabolism
2016;31(3):402-409
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The purpose of this study was to investigate the relationship between statin eligibility and the degree of renal dysfunction using the Adult Treatment Panel (ATP) III and the American College of Cardiology (ACC)/American Heart Association (AHA) guidelines in Korean adults. METHODS: Renal function was assessed in 18,746 participants of the Kangbuk Samsung Health Study from January 2011 to December 2012. Subjects were divided into three groups according to estimated glomerular filtration rate (eGFR): stage 1, eGFR ≥90 mL/min/1.73 m2; stage 2, eGFR 60 to 89 mL/min/1.73 m2; and stages 3 to 5, eGFR <60 mL/min/1.73 m2. Statin eligibility in these groups was determined using the ATP III and ACC/AHA guidelines, and the risk for 10-year atherosclerotic cardiovascular disease (ASCVD) was calculated using the Framingham Risk Score (FRS) and Pooled Cohort Equation (PCE). RESULTS: There were 3,546 (18.9%) and 4,048 (21.5%) statin-eligible subjects according to ATP III and ACC/AHA guidelines, respectively. The proportion of statin-eligible subjects increased as renal function deteriorated. Statin eligibility by the ACC/AHA guidelines showed better agreement with the Kidney Disease Improving Global Outcomes (KDIGO) recommendations compared to the ATP III guidelines in subjects with stage 3 to 5 chronic kidney disease (CKD) (κ value, 0.689 vs. 0.531). When the 10-year ASCVD risk was assessed using the FRS and PCE, the mean risk calculated by both equations significantly increased as renal function declined. CONCLUSIONS: The proportion of statin-eligible subjects significantly increased according to worsening renal function in this Korean cohort. ACC/AHA guideline showed better agreement for statin eligibility with that recommended by KDIGO guideline compared to ATP III in subjects with CKD.
