Apolipoprotein E4: A Risk Factor for Successful Cognitive Aging.
10.12779/dnd.2016.15.3.61
- Author:
Oh Dae KWON
1
Author Information
1. Department of Neurology, School of Medicine, Catholic University of Daegu, Daegu, Korea. dolbaeke@cu.ac.kr
- Publication Type:Review
- Keywords:
apolipoprotein E;
polymorphism;
Alzheimer's disease
- MeSH:
Alleles;
Alzheimer Disease;
Amyloid;
Apolipoprotein E4*;
Apolipoproteins*;
Atherosclerosis;
Brain;
Central Nervous System;
Cognitive Aging*;
Metabolism;
Pathology;
Plasma;
Risk Factors*
- From:Dementia and Neurocognitive Disorders
2016;15(3):61-67
- CountryRepublic of Korea
- Language:English
-
Abstract:
Apolipoprotein E is a plasma protein that has an important role in transport and metabolism of lipids in serum as well as central nervous system. Among the 3 common alleles, the ε2 allele has the most stable structure followed by ε3 and ε4 in order. There is evidence for a deleterious role of ε4 allele by atherosclerosis and amyloid beta accumulation in brain and body. The presence and gene dose of ε4 allele are risk factors for late-onset Alzheimer's disease. Apolipoprotein E ε4 may have a role in the pathology of amyloid beta and tau and it has a strong relationship with the early onset of late-onset Alzheimer's disease. However, early-onset Alzheimer's disease has a weaker relationship with ε4 allele of apolipoprotein E.
